kringle domain การใช้

• In native plasminogen the PAN domain is associated with five Kringle domains.
• "' Kringle Domains "'are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages.
• In addition to a C-terminal chymotrypsin-like serine protease domain, plasminogen contains an Kringle domains ( KR1-5 ).
• PEDF expression is upregulated by plasminogen kringle domains 1-4 ( also known as angiostatin ) and the kringle 5 ( K5 ) domain.
• The Pan-Apple domain contains important determinants for maintaining plasminogen in the closed form, and the kringle domains are responsible for binding to lysine residues present in receptors and substrates.